Define biotransformation Describe the aims and outcomes of Biotransformation Enlist phase I and phase II biotransformation reactions Describe the clinical significance of biotransformation Enlist factors affecting biotransformation of a drug Define enzyme induction & enzyme inhibition Describe the clinical significance of enzyme induction and enzyme inhibition Enlist enzyme inducers and enzyme inhibitors

Slides

• Mechanisms of drug metabolic pathway inside the liver
• What is the PO form of drug administration?
• What are the two ways in which drugs can be eliminated
• What are xenobiotics
• What is the fate of xenobiotics
• What is biotransformation of drugs
• An example of drugs which are converted from active to inactive metabolite
• Example of prodrugs which are converted into active metabolites (inactive to active)
• Example of Inactive drug (prodrug) being converted into active metabolite
• Examples of active drug converted into highly toxic metabolite
• What is the antidote of the aceteminophen induced hepatotoxicity?
• By which processes do the phase 1 reactions uncover or add a functional group to the drug molecule
• In phase 2 reactions the drugs are conjugated to which molecules
• Which two types of enzymes end up catalyzing the phase 1 reactions
• What are microsomal enzymes
• What is the naming system of the CYP families
• The most abundant CYP 450 enzyme