Define absorption of drugs. Describe the factors affecting the absorption of drugs Define bio-availability of a drug Define first pass effect Discuss clinical significance of first pass effect

Slides

• Absorption
• Extent of Absorption, and the problem with drugs being too hydrophilic and too lipophilic
• Rate of Absorption
• Difference between Zero order and First Order Rate of Absorption
• Bioavailability
• First Pass Effect
• What are the two types of passive diffusion?
• What are the factors inside the drugs which affect drug absorption
• What are the factors of the human body which affect the absorption of drug
• What is the problem with strongly acidic and strongly basic drugs and their relation with the pH
• What is lipid water partition coefficient?
• The bioavailability of drugs given through the IM injection
• The bioavailability of drugs given through the transdermal route
• What are the biological factors which affect the drug absorption
• Gastrointestinal motility
• Blood flow / Vascularity
• Area of absorbing surface and Fick’s law