Define clearance Enlist factors affecting total clearance Define half-life Describe the clinical significance of half-life of drug Define steady state concentration Discuss the relationship between half-life and steady state concentration Describe first and zero order elimination with examples

• What is drug clearance
• differences between drug elimination, excretion, and clearance in pharmacology
• What are the two formulas for clearance of drug
• The formula for rate of elimination
• What is the formula for renal clearance
• What is specific organ clearance
• Factors which affect drug clearance
• what are oat and oct in plasma protein binding of the drug
• How does the pH of urine determine the reabsorption of drug
• What is the Normal GFR
• What is the meaning of GFR
• What is used as a marker for Renal Clearance Rate
• What are the two post filtration processes which happen inside the kidney tubules which affect the renal clearance
• What is Normal Plasma Renal Clearance
• How can a drug have a renal plasma clearance which exceeds the GFR?
• The normal renal plasma clearance is
• If a renal clearance is more than 120 ml/min but less then 650 ml/min
• If the renal clearance is less than 120 ml/min