Define drug distribution Describe factors affecting drug distribution Define volume of distribution (Vd) Describe the clinical significance of Vd Define loading dose & maintenance dose Discuss the clinical significance of giving drugs through loading dose & maintenance dose Describe plasma protein binding of the drugs with its clinical significance

(slides)

• Distribution
• Volume of Distribution
• What does a small Vd mean
• What does a large Vd mean
• An example of a drug with small Vd
• Why is hemodialysis useful for drugs with a small Vd
• An example of a drug with a large Vd
• When can the Vd exceed total body volume
• Factors affecting drug distribution
• Drugs which are lipid soluble (lipophillic) and unionized
• Strongly acidic and basic drugs which are always ionized are confined to intravascular compartment, example
• Lipid soluble drugs reach all compartments thus may end up accumulating inside
• Lipid Insoluble drugs are mainly confined to plasma and interstitial fluids and do not enter mostly, which organ?
• Drugs are rapidly distributed to which kinds of tissues
• Where are drugs more slowly distributed to according to blood flow
• What is tissue storage
• Where is digoxin sequestered